Antimicrobial resistance in pathogenic bacteria has become a serious public health concern as infections with multi-drug resistant bacteria are becoming increasingly difficult to treat.  In a recent publication by Hatosy and Martiny, the diversity of antimicrobial resistance genes in marine systems was explored using functional metagenomics.  Work from these authors, as well as other studies of antimicrobial resistance in non-clinical environments, emphasize the need for a One Health approach to address problems associated with antimicrobial use and resistance.