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    ISSN : 2328-9791
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New mechanistic insight of Wnt5a inhibition involving ROR1
     
 
Md Kamrul Hasan. Ph.D.
University of California San Diego
Department of Medicine, UCSD, 9500 Gilman Dr., La Jolla, CA 92093, USA
k0hasan@ucsd.edu

Wnt5a is one of the most extensively studied proteins of the Wnt family and is known to play an important role in cellular motility and proliferation. Wnt5a is a ligand of the receptor tyrosine kinase-like orphan receptor 1 (ROR1), an onco-embryonic protein expressed on chronic lymphocytic leukemia (CLL) B cells, and on a variety of solid tumors, but not on normal adult tissues. This mini-review summarizes recent results regarding the inhibition of effects of Wnt5a signaling by targeting ROR1. 

 
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