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The Role of Microglia in Alzheimer's Disease
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Kim Wilkinson
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Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
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kwilkinson9@gmail.com
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Alzheimer's disease is a devastating neurological condition for which there is no known cure. Inflammation in the brain has been implicated in development of pathology, and of particular interest are the microglia, a major phagocytic cell population. Microglia are able to bind to and engulf amyloid-B (AB), a protein that forms fibrils that accumulate as plaques. However,despite increased numbers of activated microglia surrounding AB plaques, there is continued neuronal destruction.......
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