Oxidative Stress and Inflammation : 'THE LESSER OF TWO EVILS' In Carcinogenesis

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ISSN : 2328-9791

Oxidative Stress and Inflammation : 'THE LESSER OF TWO EVILS' In Carcinogenesis

Naveen Kaushal and Avinash K. Kudva

The Pennsylvania State University

Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA

nuk12@psu.edu

Literature is replete with reports indicating the involvement of oxidative stress and inflammation in tumorigenesis. Reactive oxygen species (ROS) are by-products of various oxidized cellular metabolites that serve as the â€œbusiness endâ€ as well as the consequence of oxidative stress leading to DNA damage, mutagenesis, and destruction of diverse biological macromolecules. These events may eventually culminate in carcinogenesis- through varied mechanisms such as inhibition of apoptosis, increased cellular proliferation, angiogenesis, and disruption of DNA repair mechanism. Inflammation per se.....