A new ‘rotational’ twist in an old tale: mammary epithelial cells ‘weave’ a laminin matri

A Journal of Postdoctoral Research.

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ISSN : 2328-9791

A new ‘rotational’ twist in an old tale: mammary epithelial cells ‘weave’ a laminin matri

Rajeshwari R. Valiathan

Wayne State University School of Medicine.

Department of Pathology, Detroit, MI.

rvaliath@med.wayne.edu

That single adult mammary epithelial cells are capable of recapitulating entire mammary gland structure and function when grown in three-dimensional laminin-rich basement membrane (3D lrBM) matrices is a phenomenon that was observed over two decades ago [1]. However, the underlying mechanisms still remain elusive. Moreover, why malignant cells are incapable of this behavior is unknown [2-4]. Clearly, mammary epithelial cells must have a morphogenetic program that is lost during malignant transformation. To understand this better, Wang et al utilized real-time imaging techniques to visualize the behavior of single non-malignant and malignant mammary epithelial cells as they formed spheroids or acini in 3D lrBM matrices. Their unexpected findings.......