Investigation of Poly(amidoamine) Dendrimer Based Simvastatin Oral Formulations: Pharmaco

A Journal of Postdoctoral Research.

Jobs

Article

Authors

ISSN : 2328-9791

Investigation of Poly(amidoamine) Dendrimer Based Simvastatin Oral Formulations: Pharmaco

Leyuan Xu, Hao Zhang, and Yue Wu.

Virginia Commonwealth University.

Richmond, Virginia 23284 USA

wuy@vcu.edu

Statin is known as 3â€hydroxyâ€3â€methylglutaryl coenzyme A (HMGâ€CoA) reductase inhibitor and is used to treat patients with hypercholesterolemia. Simvastatin (SMV) is a member in the statin class of pharmaceuticals; it is costâ€effective and has relatively few adverse effects. Thus, SMV becomes the best choice in initial therapy for hypercholesterolemia. However, SMV is severely limited by its poor aqueous solubility and low oral bioavailability through the gastrointestinal track. Such drawbacks could be gentled by a drug delivery system, which can efficiently deliver SMV and
improve pharmacokinetics of SMV. Dendrimers have been extensively utilized for construction of nanocarriers in drug delivery systems. Dendrimers have a highly branched nanoscalearchitecture with low polydispersity and high functionality. This unique architecture allows for.....