Exploring a New Role for Molecular Chaperones in Protein Folding

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ISSN : 2328-9791

Exploring a New Role for Molecular Chaperones in Protein Folding

Bharat Jagannathan

UC Berkeley

California Institute for Quantitative Biosciences, University of California, Berkeley, USA.

Protein folding is a remarkable biological process in which proteins are transformed from linear amino acid sequences into complex three-dimensional structures. Errors during protein folding can lead to neurodegenerative ailments such as Alzheimer's disease and Parkinson's disease. Although the precise in vivo mechanism of this important process remains poorly understood, a network of molecular chaperone proteins are thought to play a crucial role in guiding a protein towards its correct conformation. It has been previously reported that these chaperones assist protein folding by suppressing aggregation, as well as by rescuing misfolded states (Hartl et al., 2011). However,.....