Tube Morphogenesis - THE EXTRAcellular DIMENSION | Society of Life Sciences (SoLS)

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ISSN : 2328-9791

Tube Morphogenesis - THE EXTRAcellular DIMENSION

Rajprasad Loganathan

The Johns Hopkins University School of Medicine

Department of Cell biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

rlogana2@jhmi.edu

The human body is replete with tubular organs that are essential for the secretion, transport, exchange, and storage of vital fluids. These organs sustain human physiology by virtue of the salient features of a select group of cells that support tubular architectures. Hence, a fundamental question in developmental biology concerns how cells interact with each other to form tubular structures during early embryogenesis. Increasing evidence suggests that in addition to the role played by the cells themselves, the extracellular matrix (ECM) also contributes to tube morphogenesis.......