Snail genes and embryonic bone development | Society of Life Sciences (SoLS)

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ISSN : 2328-9791

Snail genes and embryonic bone development

Ying Chen

Tufts University

Department of Biomedical Engineering, Tufts University, Medford MA, USA

ying.chen@tufts.edu

In the past two decades, Snail family genes have been extensively studied in mouse development and cellular function, including the regulation of epithelial-mesenchymal transitions (EMTs) during both embryonic development and metastasis of epithelial tumors, cell survival and cell death, the determination of cell fate, and the establishment of left-right asymmetry. However, their role in bone development is not as widely reported. The purpose of this review is to briefly overview embryonic long bone development and summarize recent studies that provide evidence for Snail signaling in long bone development....