log  
logo
A Journal of Postdoctoral Research.
 
     Login   |   Register   
    ISSN : 2328-9791
left right
 
 
JAK Inhibition Induces Browning of White Adipocytes
     
 
Vidisha Raje
University of Virginia

Department of Pharmacology, UVA, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA

vbr9n@virginia.edu

The global epidemic of obesity is increasing at an alarming rate, posing a severe threat to human health. The accumulation of excess white adipose tissue in obese individuals increases their risk for type 2 diabetes, cardiovascular diseases, hypertension, stoke and even cancer. Current efforts manifest the need to identify potential anti-obesity therapeutics. One promising approach is increasing the activity of ‘brown like’ adipocytes in white adipose depots, which has been shown to improve the overall metabolic phenotype of the organism. This report by Moisan and coworkers demonstrates a novel and a promising approach by inhibiting JAK kinases to induce browning in white adipose tissue.  

 
btm
 
top
 
 
 
 
 
btm

 
footer
 
 
home phone mail info@postdocjournal.com
 
twitter facebook social icon Social link You Tube sky
Click Here