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    ISSN : 2328-9791
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  Dr. SUSHAMA SIVAKUMAR  
 
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Title : Dr.
First Name : SUSHAMA
Last Name : SIVAKUMAR
University/Institution : UT Southwestern medical center
Email ID : sushama.sivakumar@utsouthwestern.edu
City : Dallas
Country : United States
State : Texas
Zipcode : 75390
Department : Pharmacology
Company Name :
Area of Research
Mitosis, cell cycle, DNA replication
Area of Expertise
Aneuploidy, mitosis, chromosome stability, cell cycle
Brief Description of Research Interest :
I am interested in studying regulation of the cell cycle and understanding the process of mitosis. Errors in mitosis or mis-regulation  of the cell cycle causes genomic instability and tumorigenesis. We are interested in elucidating how the errors occur during the cell cycle and how cells repair the damage to maintain accurate DNA content.  
Representative Publications :

ZhangQ, Sivakumar S, Chen Y, Gao H, YangL, Yuan Z, Yu H, and Liu H. “Ska3 phosphorylated by Cdk1 binds Ndc80 andrecruits Ska to kinetochores to promote mitotic progression”. Current biology, May 22 2017, 27,1-8

 

Sivakumar S, Janczyk P, Qu Q, Brautigam CA, Stukenberg PT,YuH, Gorbsky GJ. “The Ska complex drives themetaphase-anaphase cell cycle transition by recruiting Protein Phosphatase 1 tokinetochores”. eLife, 2016;5:e12902  

 

Lee S, Kopp F, Chang TC, Sataluri A, Chen B, Sivakumar S, Yu H, Xie Y, Mendell JT. “NoncodingRNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins”. Cell, 2016. 164(1-2):69-80  


Sivakumar S, Gorbsky GJ. “Spatiotemporal regulation of the Anaphase promoting complex in mitosis”. Nature Rev Mol Cell Biology, 2015.16(2):82-94 


Sivakumar S, Daum JR, Tipton AR, Rankin S, Gorbsky GJ. “The spindle and kinetochore-associated (Ska) complex enhances binding of the Anaphase Promoting Complex/Cyclosome (APC/C) to chromosomes and promotes mitotic exit ”. Mol Biol Cell, 2014. 25(5):594-605

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