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Dr. NAJLA ARSHAD
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Address 1
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Address 2
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Title
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Dr.
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First Name
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NAJLA
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Last Name
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ARSHAD
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University/Institution
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Yale University School of Medicine
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Phone #
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2037372452
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Email ID
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najla.arshad@yale.edu
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City
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New Haven
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Country
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United States
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State
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Connecticut
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Zipcode
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06520
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Department
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Immunobiology
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Company Name
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Area of Research
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Yale University School of Medicine
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Area of Expertise
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Biochemistry and cell biology
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Brief Description of Research Interest :
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My interest lies in examining how protein biochemistry is altered in disease. My doctoral work identified the biochemical basis of a familial disease caused by a mutation in the membrane-associated receptor guanylyl cyclase C (GC-C). I also analyzed how glycosylation of GC-C affects its function, trafficking, and interactions with novel lectin chaperones.
I am currently working on the process of peptide loading and antigen presentation of major histocompatibility complex class I (MHC-I) molecules. I investigate how the interactions between MHC-I, a glycosylated protein, and members of the ER-quality control pathway affect peptide loading and antigen presentation during viral infection and cancer.
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Representative Publications :
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Fiskerstrand T*, Arshad N*, Haukanes BI, Tronstad RR, Pham KD, Johansson S, Håvik B, Tønder SL, Levy SE, Brackman D, Boman H, Biswas KH, Apold J, Hovdenak N, Visweswariah SS, Knappskog PM. Familial diarrhea syndrome caused by an activating GUCY2C mutation. N Engl J Med. 2012 Apr 26;366(17):1586-95. PubMed PMID: 22436048. *co-first author
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Arshad N, Ballal S, Visweswariah SS. Site-specific N-linked glycosylation of receptor guanylyl cyclase C regulates ligand binding, ligand-mediated activation and interaction with vesicular integral membrane protein 36, VIP36. J Biol Chem. 2013 Feb 8;288(6):3907-17. PubMed PMID: 23269669
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Arshad N, Visweswariah SS. Cyclic nucleotide signaling in intestinal epithelia: getting to the gut of the matter. Wiley Interdiscip Rev Syst Biol Med. 2013 Jul-Aug;5(4):409-24. PubMed PMID: 23610087.
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